Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice

Manabu Nakazono; Shigeo Hasegawa; Tsuneyuki Yamamoto; Kiyoshi Zaitsu

doi:10.1016/j.bmcl.2004.08.053

Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5619-21. doi: 10.1016/j.bmcl.2004.08.053.

Authors

Manabu Nakazono¹, Shigeo Hasegawa, Tsuneyuki Yamamoto, Kiyoshi Zaitsu

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

PMID: 15482935
DOI: 10.1016/j.bmcl.2004.08.053

Abstract

The 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene was synthesized from N,N'-di(1-adamantyl)malondiamide and C(60) in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene. The intraperitoneal administration of this fullerene derivative (10mg/kg) caused an antagonistic effect on haloperidol-induced catalepsy in mice.

MeSH terms

Adamantane / analogs & derivatives*
Adamantane / chemical synthesis*
Adamantane / pharmacology
Animals
Catalepsy* / chemically induced
Catalepsy* / drug therapy
Fullerenes / chemistry*
Fullerenes / pharmacology
Haloperidol*
Injections, Intraperitoneal
Male
Mice
Mice, Inbred Strains
Molecular Structure

Substances

61-bis(1-adamantylcarbamoyl)-1,2-methano(60)fullerene
Fullerenes
Haloperidol
Adamantane